Improved persistence and expanded TPEX formation in Regnase-1 KO CAR T cells is TCF-1-dependent

ABSTRACT: transcriptional profiling was performed on Regnase-1 KO CAR and Regnase-1 TCF-1 DKO CAR T cells isolated 7days after co-transfer into tumor bearing mice. TCF-1 deficiency in Regnase-1 KO CAR T cells led to reduced long-term persistence and memory-like phenotype.

ORGANISM(S): Mus musculus

PROVIDER: GSE155020 | GEO | 2021/04/07

REPOSITORIES: GEO