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RNA-seq data from mouse newborn rib chondrocytes

ABSTRACT: To understand the targets of Sox5, Sox6 and Sox9, we overexpressed Sox5/6/9 in mouse newborn rib chondrocytes and expression analysis by RNA-seq.

ORGANISM(S): Mus musculus

PROVIDER: GSE155118 | GEO | 2021/01/20

REPOSITORIES: GEO

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RNA-seq data from mouse newborn rib chondrocytes

Project description:RNA-seq data from mouse newborn rib chondrocytes

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The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis (RNA-Seq)

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Expression profiles from chondrocytes in culture - time course

Project description:To characterize the process of chondrocyte differentiation and maturation, we used Affymetrix GeneChip analysis to profile the dynamic changes in mRNA expression in high density cultures of primary rib chondrocytes from newborn mice. Temporal expression profiles were obtained from RNA harvested from chondrocytes cultured for 2, 6, 9, 12 and 15 days. Progressive maturation of cells into cartilage-producing hypertrophic chondrocytes was accompanied by changes of expression for many genes, particularly genes encoding extracellular matrix components and transcription factors.

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