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Characterization of the brain infiltrating leukocytes in 3xTg-AD mice [Pools of 10 female mice brain]

ABSTRACT: We characterize the brain infiltrating leukocyte (CD45high cells) in wild-type and 3xTg-AD mice, a transgenic model of Alzheimer's disease (AD).

ORGANISM(S): Mus musculus

PROVIDER: GSE155214 | GEO | 2025/05/29

REPOSITORIES: GEO

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Characterization of the brain infiltrating leukocytes in 3xTg-AD mice [Pools of 8 female mice brain]

Project description:We characterize the brain infiltrating leukocyte (CD45high cells) in wild-type and 3xTg-AD mice, a transgenic model of Alzheimer's disease (AD).

2025-05-29 | GSE180184 | GEO

Characterization of the meningeal leukocytes in 3xTg-AD mice

Project description:We characterize the meningeal leukocyte (CD45+ cells) in wild-type and 3xTg-AD mice, a transgenic model of Alzheimer's disease (AD).

2025-05-29 | GSE180188 | GEO

Characterization of the brain infiltrating leukocytes in 3xTg-AD mice [Pools of 8 female mice brain]

Project description:Characterization of the brain infiltrating leukocytes in 3xTg-AD mice [Pools of 8 female mice brain]

| PRJNA746994 | ENA

Characterization of the brain infiltrating leukocytes in 3xTg-AD mice [Pools of 10 female mice brain]

Project description:Characterization of the brain infiltrating leukocytes in 3xTg-AD mice [Pools of 10 female mice brain]

| PRJNA648980 | ENA

Characterization of the meningeal leukocytes in 3xTg-AD mice

Project description:Characterization of the meningeal leukocytes in 3xTg-AD mice

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scRNA-sequencing of in vitro cultured ILC2 from the whole brain tissue of 7 months old 3xTg-AD and Control mice.

Project description:ILC2 are potent producers of IL-5 and IL-13 and Th2 cytokines. We have found that 3xTg-AD mice exhibit diminished ILC2 numbers and functionality in the brain barriers. We have found through scRNA-seq that cultured brain ILC2 from 7 months old 3xTg-AD mice expressed significantly less IL-5 ane Areg but increased Gzma and Gzmb.

2021-07-14 | GSE161861 | GEO

large scale brain proteome profiling of 3xtg mice

Project description:A large scale profiling of 3xtg mouse brain to invetigate the AD proteomic phenotype.

2024-06-25 | PXD053314 | Pride

Whole Blood Transcriptome Characterization of 3xTg-AD Mouse and its modulation by transcranial Direct Current Stimulation (tDCS)

Project description:The 3xTg-AD mouse is a widely used model in the study of Alzheimer’s Disease (AD). It has been extensively characterized both from the anatomical and behavioral point of view but poorly studied at the transcriptomic level. For the first time, this study characterizes the whole blood transcriptome of the 3xTg-AD mouse at three and six months of age and evaluates how gene expression is modulated by transcranial direct current stimulation (tDCS). RNA-seq analysis revealed 183 differentially expressed genes (DEGs) that were a direct signature of the genetic background of the mouse. The expression profile of age-related genes in the 3 months-old 3xTg-AD mice was more similar to that of 6 months rather than 3 months-control mice, suggesting a premature aging of the 3xTg-AD mice. Moreover, in the 6 months-old 3xTg-AD mice, we observed a high number of DEGs that could represent good peripheral biomarkers of AD progression. Finally, tDCS was associated with gene expression changes in the 3xTg-AD but not in the control mice. In conclusion, this study provides a better molecular characterization of the 3xTg-AD mouse and suggests that blood gene expression can be used to identify new biomarkers of AD progression and treatments effect.

2021-07-19 | GSE178662 | GEO

Proteomic Profiling of the Hippocampus in Lithium-Deficient 3xTg-AD Mice

Project description:This proteomics experiment aimed to identify proteins whose abundance is altered by lithium deficiency in the context of Alzheimer's disease pathology in mice. Female homozygous 3xTg-AD mice were continuously fed either a lithium-deficient or a control diet from 6 to 15 months of age. At the end of the treatment period, mice (n=4 per group) were sacrificed, perfused transcardially with PBS, and their hippocampi were extracted for proteomic analysis.

2025-06-09 | PXD063039 | Pride

Senescent cell elimination modifies features of Alzheimer’s disease in 3xTg-AD mice

Project description:Cellular senescence has been associated with neurodegenerative disease and clearance of senescent cells using genetic or pharmaceutical strategies (senolytics) has demonstrated beneficial effects in mouse models investigating individual disease etiologies of Alzheimer’s disease (AD). However, it has remained unclear if senescent cell clearance in a mouse model exhibiting both plaque and tau pathologies modifies the disease state (3xTg). Here, we show that treatment with senolytics (ABT263 (navitoclax) or a combination of dasatinib and quercetin (D+Q)) or transgenic removal of p16-expressing cells (via INK-ATTAC) reduced microgliosis and ameliorated both amyloid and tau pathology in 3xTg mice. Using RNA sequencing, we found evidence that synaptic dysfunction and neuroinflammation was attenuated with senescent cell removal. Unfortunately, these beneficial effects were not seen with short-term senolytic treatment in mice with more advanced disease. Overall, our results further corroborate the beneficial effects senescent cell clearance could have on AD and highlight the importance of early intervention for treatment of this debilitating disease.

2024-03-20 | GSE231332 | GEO

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