Global RNA-sequencing of a pediatric AML primary sample treated with Tamibarotene or vehicle

ABSTRACT: The purpose of this study was to assess the global transcriptional changes in a pediatric AML primary sample treated with Tamibarotene. This patient sample has a retinoic acid receptor alpha (RARA) super-enhancer, which is correlated with higher RARA mRNA levels and increased sensitivity to Tamibarotene in vitro and in vivo (Patient-derived xenograft mouse model).

ORGANISM(S): Homo sapiens

PROVIDER: GSE155559 | GEO | 2021/08/01

REPOSITORIES: GEO