Transcriptomic profiling of blood memory B cell subsets in kidney transplant recipients

ABSTRACT: We compared the transcriptomic profile between patients without donor-specific antibodies (DSA-), patients with donor-specific antibodies without antibody-mediated rejection (DSA+ ABMR-) and patients with donor-specific antibodies and antibody-mediated rejection (DSA+ ABMR+). We found that patients with DSA+ ABMR+ had a distinct transcriptomic profile compared to DSA- and DSA+ ABMR- patients, characterized by upregulation of genes related to B cell activation and B cell effector functions.

ORGANISM(S): Homo sapiens

PROVIDER: GSE155670 | GEO | 2021/07/14

REPOSITORIES: GEO