Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression by LASP1 knocked down in PC3 cells

ABSTRACT: The aim of this research was to confirm the regulatory effect of LASP1 on gene expression in the development of prostate cancer.

ORGANISM(S): Homo sapiens

PROVIDER: GSE155731 | GEO | 2022/07/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Gene expression by BTF3 knocked down in Vcap cells

Project description:The aim of this research was to confirm the regulatory effect of BTF3 on gene expression in the development of prostate cancer.

2019-06-21 | GSE122749 | GEO

Gene expression by LASP1 knocked down in PC3 cells

Project description:Gene expression by LASP1 knocked down in PC3 cells

| PRJNA655418 | ENA

Gene expression by TRPS1 knocked down in T47D

Project description:The aim of this research was to confirm the regulatory effect of TRPS1 on gene expression in the development of breast cancer.

2018-11-19 | GSE104062 | GEO

Gene expression by BTF3 knocked down in MDA-MB-231 cells

Project description:The aim of this research was to confirm the regulatory effect of BTF3 on gene expression in the development of TNBC.

2022-07-01 | GSE155168 | GEO

Regulation of matrix metalloproteinases (MMPs) expression and secretion by LIM and SH3 protein (LASP1)

Project description:The process of tumor invasion requires degradation of extracellular matrix by proteolytic enzymes. Cancer cells form protrusive invadopodia, which produce and release matrix metalloproteinases (MMPs) to degrade the basement membrane and thereby allowing metastasis. We investigated the effect of LASP1, a newly identified protein in invadopodia, on expression, secretion and activation of MMPs in invasive breast tumor cells. By analyzing and verifying microarray data sets and performing reporter assays, we demonstrate that LASP1 positively modulates the expression of c-Fos and AP-1 activity, and thereby up-regulates expression of MMP1, -3 and -9 in breast cancer cells. Furthermore, zymography assays and Western blot analysis revealed cytosolic LASP1 promotion of MMP vesicle secretion into the extracellular matrix, thus altering the microenvironment during cancer progression. The newly identified role of LASP1 in regulating matrix degradation by affecting MMP transcription and secretion elucidated the migratory potential observed in studies that investigated the upregulation of LASP1 in aggressive cancers.

2017-02-03 | GSE77584 | GEO

Gene expression by basic transcription factor 3 (BTF3）knocked out in HCT116

Project description:The aim of this research was to confirm the regulatory effect of basic transcription factor 3 (BTF3) on gene expression in the development of rectal cancer.

2017-03-18 | GSE96755 | GEO

Lasp1 gene disruption is linked to enhanced cell migration and tumor formation

Project description:Chronic loss of Lasp1 alters the expression of other genes associated with cell motility/attachment, and/or other cellular functions. Results provide new information showing that loss of Lasp1 leads to up- and down-regulation of genes involved in cell motility/attachment/growth. Keywords: Genotype comparison Total RNA isolated from Lasp1-/- MEFs compared to Lasp1+/+ MEFs.

2010-06-23 | E-GEOD-14800 | biostudies-arrayexpress

RUVBL1 promotes enzalutamide resistance of prostate tumors through the PLXNA1-CRAF-MAPK pathway

Project description:The aim of this research was to confirm the regulatory effect of RUVBL1 on gene expression in castration resistant prostate cancer.

2022-03-02 | GSE197630 | GEO

KIF15 confers resistance to enzalutamide in castration resistant prostate cancer [RNA-Seq]

Project description:The aim of this research was to confirm the regulatory effect of KIF15 on gene expression in castration resistant prostate cancer.

2021-05-20 | GSE150895 | GEO

KIF15 confers resistance to enzalutamide in castration resistant prostate cancer [array]

Project description:The aim of this research was to confirm the regulatory effect of KIF15 on gene expression in castration resistant prostate cancer.

2021-05-20 | GSE146984 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data