Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

HDAC2 maintains receptor tyrosine kinase signaling of undifferentiated pancreatic cancer cells (ATAC-Seq)

ABSTRACT: H3K27ac ChIP-se and ATAC-seq were used to determine epigenetic differences between Hdac2 knockout versus Hdac2 wildtype pancreatic cancer cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE155751 | GEO | 2021/11/12

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

HDAC2 maintains receptor tyrosine kinase signaling of undifferentiated pancreatic cancer cells (ChIP-Seq)

Project description:H3K27ac ChIP-se and ATAC-seq were used to determine epigenetic differences between Hdac2 knockout versus Hdac2 wildtype pancreatic cancer cells.

2021-11-12 | GSE155752 | GEO

HDAC2 maintains receptor tyrosine kinase signaling of undifferentiated pancreatic cancer cells

Project description:HDAC2 maintains receptor tyrosine kinase signaling of undifferentiated pancreatic cancer cells

| PRJNA655480 | ENA

HDAC2 maintains receptor tyrosine kinase signaling of undifferentiated pancreatic cancer cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-11-12 | GSE155753 | GEO

HDAC2 maintains receptor tyrosine kinase signaling of undifferentiated pancreatic cancer cells (ChIP-Seq)

Project description:HDAC2 maintains receptor tyrosine kinase signaling of undifferentiated pancreatic cancer cells (ChIP-Seq)

| PRJNA655482 | ENA

HDAC2 maintains receptor tyrosine kinase signaling of undifferentiated pancreatic cancer cells (ATAC-Seq)

Project description:HDAC2 maintains receptor tyrosine kinase signaling of undifferentiated pancreatic cancer cells (ATAC-Seq)

| PRJNA655483 | ENA

Role of Hdac2 in pancreatic ductal adenocarcinoma

Project description:Microarrays were used to determine transcriptional differences between Hdac2 knockout versus Hdac2 wildtype pancreatic cancer cells.

2020-02-06 | GSE144798 | GEO

Genome-wide chromatin binding of Hdac2 in murine PDAC cells (ChIP-Seq)

Project description:Hdac2 ChIP-seq were used to determine epigenetic differences between Hdac2 knockout versus Hdac2 wildtype pancreatic cancer cells. DOI: 10.1158/0008-5472.can-20-3209

2021-11-11 | GSE183823 | GEO

HDAC2 facilitates metastasis of pancreatic cancer cells

Project description:HDAC2 facilitates pancreatic cancer metastasis

| PRJEB47385 | ENA

Hypoxa-actived XBP1s recruits HDAC2-EZH2 to engage epigenetic suppression of DNp63 expression and promotes breast cacner metastasis independent HIF1a

Project description:Hypoxia is a hallmark of cancer development. However, the molecular mechanisms by which hypoxia promotes tumor metastasis are not fully understood. In this study, we demonstrate that hypoxia promotes breast cancer metastasis through suppression of ΔNp63α-dependent in a HIF1α-independent manner. We show that hypoxia activates unfolded protein response (UPR) to elevate XBP1s, which in turn forms stable repressor protein complexes with HDAC2 and EZH2 in suppression of ΔNp63α. Notably, while H3K27ac is predominantly presented in the ΔNp63 promoter under normoxia, it is switched to H3K27me3 under hypoxia. We show that XBP1s binds to the ΔNp63 promoter to recruit HDAC2 and EZH2 in facilitating the H3K27ac-H3K27me3 switch. Knockdown or pharmacological inhibition of either HDAC2 or EZH2 leads to increased H3K27ac concomitant with reduced H3K27me3, which effectively restores ΔNp63α expression suppressed by hypoxia, resulting in inhibition of cell migration. Clinical analyses reveal that reduced p63 expression is correlated with the elevated expression of XBP1, HDAC2, or EZH2, and is associated with poor overall survival in human breast cancer patients. Together, these results indicate that hypoxia-activated XBP1s modulates the epigenetic program in suppression of ΔNp63α to promote breast cancer metastasis independent of HIF1α and provides a molecule basis for targeting the XBP1s/HDAC2/EZH2-ΔNp63α axis as a putative strategy in the treatment of breast cancer metastasis.

2024-01-24 | GSE253833 | GEO

Role of Hdac2 in pancreatic ductal adenocarcinoma

Project description:Role of Hdac2 in pancreatic ductal adenocarcinoma

| PRJNA604969 | ENA