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Identification and Characterization of Cellular Heterogeneity within the Developing Renal Interstitium

ABSTRACT: Kidney formation requires the coordinated growth of multiple cell types including the collecting ducts, nephrons, vasculature and interstitium. We show that during development, the interstitium is a highly heterogeneous, patterned population of cells that occupies distinct positions correlated to the adjacent parenchyma. Our analysis indicates that the heterogeneity is not a mere reflection of different stages in a linear developmental trajectory but instead represents several novel differentiated cell states. Further, we find that beta-catenin has a cell autonomous role in the development of a medullary subset of the interstitium and that this non-autonomously affects the development of the adjacent epithelia.

ORGANISM(S): Mus musculus

PROVIDER: GSE155794 | GEO | 2020/08/07

REPOSITORIES: GEO

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