Induction of spontaneous human neocentromere formation and long-term maturation (QuantChIP-Seq)

ABSTRACT: We report a chromosome engineering system for human neocentromere formation and characterize the first experimentally generated human neocentromere. Neocentromere formation promotes local H3K9me3 eviction and cohesin and RNA polymerase II recruitment. Long-term culture results in gradual maturation of the inner centromere.

ORGANISM(S): Homo sapiens

PROVIDER: GSE155828 | GEO | 2021/01/08

REPOSITORIES: GEO