Transcriptomics,Genomics

Dataset Information

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Terminally maturing erythroblasts have dynamic changes in transcription-related chromatin modifications and RNA Polymerase II occupancy (RNA-Seq)


ABSTRACT: We suggest a novel paradigm for understanding the epigenetic mechanisms that govern terminal erythroid maturation, and underlie inherited and acquired erythroid disease.   Overall design: Two replicates of CD36 synchronization cultures at Day 7 and Day 10 are compared following RNA-seq

INSTRUMENT(S): Illumina HiSeq 2000 (Homo sapiens)

ORGANISM(S): Homo sapiens  

SUBMITTER: Zachary C Murphy  

PROVIDER: GSE155848 | GEO | 2022-01-11

REPOSITORIES: GEO

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Publications


The terminal maturation of human erythroblasts requires significant changes in gene expression in the context of dramatic nuclear condensation. Defects in this process are associated with inherited anemias and myelodysplastic syndromes. The progressively dense appearance of the condensing nucleus in maturing erythroblasts led to the assumption that heterochromatin accumulation underlies this process, but despite extensive study, the precise mechanisms underlying this essential biologic process r  ...[more]

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