RNA sequencing to identify immunity-regulated genes in C. elegans defense against pathogen infection

ABSTRACT: To understand the molecular mechanism of C. elegans innate immunity, we used RNA sequencing to profile gene expression in wild-type animals with or without P. aeruginosa (PA14) infection. We found that a bZIP transcription factor ZIP-11 is dramatically induced in wild-type worm upon PA14 infection. And ZIP-11 promotes innate immunity through activating PMK-1/p38 pathway and interacting with a CCAAT/enhancer-binding protein CEBP-2.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE155868 | GEO | 2022/12/15

REPOSITORIES: GEO