Profiling of CD14+ monocytes from humans with Type diabetes and without diabetes [RNA-Seq]

ABSTRACT: Monocyte activation by high glucose and free fatty acids promotes inflammation implicated in vascular complications associated with Type 2 diabetes (T2D). Emerging evidence shows that long non coding RNA (lncRNA)s regulate inflammation, but their role in T2D induced monocyte dysfunction is unclear. To examine this, we profiled the transcriptome of CD14+ monocytes from volunteers with T2D and without diabetes (n=5 each) using strand-specific RNA-seq on Illumina HiSeq 2500. Our study identified several differentially regulated lncRNAs along with coding genes involved in monocyte functions related to inflammation and monocytosis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE156061 | GEO | 2021/06/23

REPOSITORIES: GEO