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Bromodomain 4 inhibition leads to MYCN downregulation in Wilms’ tumor cells

ABSTRACT: We have undertaken a functional genomics approach to uncover novel therapeutic strategies efficacious for those patients with anaplastic Wilms’ tumor. Genomic analysis, in vitro chemical screens and microfluidic experiments demonstrate that MYCN over-expression in Wilms’ tumor can be modulated via BRD4 inhibition resulting in a reduction in Wilms’ tumor cell growth.

ORGANISM(S): Homo sapiens

PROVIDER: GSE156065 | GEO | 2020/08/12

REPOSITORIES: GEO

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