RNA-seq analysis of Scx-lineage cell depletion to investigate tendon cell functions during flexor tendon healing

ABSTRACT: Little is understood about the roles of tendon cells during flexor tendon healing. To better understand tendon cell functions, the Scx-Cre mouse was crossed to the DTR mouse model to facilitate scleraxis lineage cell depletion prior to acute flexor tendon injury and repair. WT (cre-) and experimental (cre+) mice underwent complete transection and repair of the flexor digitorum longus tendon. Repaired tendons were harvested at 14 and 28 days post-repair for bulk RNA-Seq analysis to examine possible mechanisms driving differential healing due to Scx lineage cell depletion.

ORGANISM(S): Mus musculus

PROVIDER: GSE156157 | GEO | 2021/02/08

REPOSITORIES: GEO