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Comparative transcriptome analysis of human skeletal muscle in response to cold acclimation and exercise training in human volunteers.

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE156249 | GEO | 2020/08/18

REPOSITORIES: GEO

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Comparative transcriptome analysis of human skeletal muscle in response to cold acclimation and exercise training in human volunteers.

Project description: Not available

| S-EPMC7487556 | biostudies-literature

Comparative transcriptome analysis of human skeletal muscle in response to cold acclimation and exercise training in human volunteers. [A391]

Project description:Background: Cold acclimation and exercise training were previously shown to increase peripheral insulin sensitivity in human volunteers with type 2 diabetes. Although cold is a potent activator of brown adipose tissue, the increase in peripheral insulin sensitivity by cold is largely mediated by events occurring in skeletal muscle and at least partly involves GLUT4 translocation, as is also observed for exercise training. Results: To investigate if cold acclimation and exercise training overlap in the molecular adaptive response in skeletal muscle, we performed transcriptomics analysis on vastus lateralis muscle collected from human subjects before and after 10 days of cold acclimation, as well as before and after a 12-week exercise training intervention. Methods: Cold acclimation altered the expression of 756 genes (422 up, 334 down, P<0.01), while exercise training altered the expression of 665 genes (444 up, 221 down, P<0.01). Principal Component Analysis, Venn diagram, similarity analysis and Rank–rank Hypergeometric Overlap all indicated significant overlap between cold acclimation and exercise training in upregulated genes, but not in downregulated genes. Overlapping gene regulation was especially evident for genes and pathways associated with extracellular matrix remodeling. Interestingly, the genes most highly induced by cold acclimation were involved in contraction and in signal transduction between nerve and muscle cells, while no significant changes were observed in genes and pathways related to insulin signaling or glucose metabolism. Conclusions: Overall, our results indicate that cold acclimation and exercise training have overlapping effects on gene expression in human skeletal muscle, but strikingly these overlapping genes are designated to pathways related to cell remodeling rather than metabolic pathways.

2020-08-18 | GSE156248 | GEO

Comparative transcriptome analysis of human skeletal muscle in response to cold acclimation and exercise training in human volunteers. [A294]

2020-08-18 | GSE156247 | GEO

Comparative transcriptome analysis of human skeletal muscle in response to cold acclimation and exercise training in human volunteers.

Project description:Comparative transcriptome analysis of human skeletal muscle in response to cold acclimation and exercise training in human volunteers.

| PRJNA657185 | ENA

Comparative transcriptome analysis of human skeletal muscle in response to cold acclimation and exercise training in human volunteers. [A294]

Project description:Comparative transcriptome analysis of human skeletal muscle in response to cold acclimation and exercise training in human volunteers. [A294]

| PRJNA657186 | ENA

Comparative transcriptome analysis of human skeletal muscle in response to cold acclimation and exercise training in human volunteers. [A391]

Project description:Comparative transcriptome analysis of human skeletal muscle in response to cold acclimation and exercise training in human volunteers. [A391]

| PRJNA657187 | ENA

Dynamics of the human skeletal muscle transcriptome in response to exercise training

Project description:This SuperSeries is composed of the SubSeries listed below.

2014-08-21 | GSE60591 | GEO

Dynamics of the human skeletal muscle transcriptome in response to exercise training

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-08-21 | E-GEOD-60591 | biostudies-arrayexpress

Metabolomic Response of Equine Skeletal Muscle to Acute Fatiguing Exercise and Training.

Project description: Not available

| S-EPMC7040365 | biostudies-literature

Exercise Training Effects on Human Skeletal Muscle DNA Methylation

Project description:This study aimed to determine skeletal muscle DNA methylation changes in a cohort of volunteers with a range of insulin sensitivities following 8-weeks of supervised exercise training. We studied 13 sedentary participants (5M/8F, 34.6 ± 3.1 years) and performed euglycemic hyperinsulinemic clamps with vastus lateralis muscle biopsies and peak aerobic activity (VO2 peak) tests before and after training. We extracted DNA from the muscle biopsies and performed global methylation using Illumina's Methylation EPIC 850K BeadChip.

2022-03-01 | E-MTAB-11282 | biostudies-arrayexpress

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