Similar Datasets
Project description:CTCF ChIP-Seq was generated in a panel of 18 ovarian cancer cell lines to identify active regulatory elements in the genome.
2024-03-26 | GSE261931 | GEO
Project description:H3K27Ac of Ovarian Cancer Cell Lines
| PRJNA657252 | ENA
Project description:Analysis of a panel of 41 human ovarian cancer cell lines for the study of ovarian cancer biology, drug response and drug sensitivity.
2012-07-01 | GSE34615 | GEO
Project description:ChIP-seq for H3K27ac or H3K9ac was performed in different platinum sensitive and resistant epithelial ovarian cancer cell lines and in sensitive A2780 cells with shRNA induced knockdown of MBD3.
2021-07-26 | GSE172510 | GEO
Project description:Histone modifications are now well-established regulators of transcriptional programs that distinguish distinct cell states. However, the kinetics of histone modification and their role in mediating rapid, signal-responsive changes in gene expression have been little studied on a genome-wide scale. Vascular endothelial growth factor A (VEGF), a major regulator of angiogenesis, rapidly triggers changes in transcriptional activity of human umbilical vein endothelial cells (HUVECs). Here we used chromatin immunoprecipitation and high throughput sequencing (ChIP-seq) to measure genome-wide changes in histone H3 acetylation at lysine 27 (H3K27ac), a marker of active enhancers {Kharchenko et al., 2011, Nature, 471, 480-5;Zentner et al., 2011, Genome Res, 21, 1273-83;Rada-Iglesias et al., 2011, Nature, 470, 279-83; Creyghton et al., 2010, Proc Natl Acad Sci U S A, 107, 21931-6 }, after 0, 1, 4, and 12 hours of VEGF stimulation. We show that sites with greatest H3K27ac changes were associated tightly with p300, a histone acetyltransferase. This dynamic H3K27ac signature defined transcriptional elements that are functionally linked to angiogenesis, participate in rapid VEGF-stimulated changes in chromatin conformation, and mediate VEGF-induced transcriptional responses. Dynamic H3K27ac deposition required p300 activity and did not involve altered nucleosome occupancy. Our results demonstrate that capture of dynamic changes in H3K27ac provides a new approach to define the activity of functional genomic elements and implicate epigenetic modifications in rapid signal-responsive transcriptional regulation. ChiP-seq timecourse of H3K27ac, ETS1, p300 chromatin occupancy, mRNA expression and DNA hypersensitivity of HUVEC cells stimulated with VEGF for 0, 1, 4, and 12 hours
2013-03-31 | E-GEOD-41166 | biostudies-arrayexpress
Project description:H3K27ac ChIP-Seq data of the T-ALL cell line LOUCY was obtained to find active regions in the genome and to correlate that with expression profiling of lncRNAs in the LOUCY cell line. ChIP-sequencing data was generated for H3K27ac in the T-ALL cell line LOUCY.
2016-05-17 | E-GEOD-74311 | biostudies-arrayexpress
Project description:This is a dataset generated by the Drosophila Regulatory Elements modENCODE Project led by Kevin P. White at the University of Chicago. It contains ChIP-chip data on Agilent 244K dual-color arrays for antibody: H3K27Ac at 12 different time-points of Drosophila development. Current Dataset: [GSM386179..GSM386187]: ChIP-chip of H3K27AC in Drosophila embryos at 0-4 hours of development [GSM386216..GSM386224]: ChIP-chip of H3K27AC in Drosophila embryos at 4-8 hours of development [GSM386334..GSM386342]: ChIP-chip of H3K27AC in Drosophila embryos at 0-4 hours of development (second dataset) [GSM418501..GSM418509]: ChIP-chip of H3K27AC in Adult male [GSM441405..GSM441410]: ChIP-chip of H3K27AC in Drosophila embryos at 8-12 hours of development [GSM441411..GSM441419]: ChIP-chip of H3K27AC in Drosophila embryos at 12-16 hours of development [GSM441420..GSM441436]: ChIP-chip of H3K27AC in Drosophila embryos at 16-20 hours of development [GSM441437..GSM441445]: ChIP-chip of H3K27AC in Drosophila embryos at 20-24 hours of development [GSM441446..GSM441931]: ChIP-chip of H3K27AC in L1 [GSM441933..GSM441941]: ChIP-chip of H3K27AC in L2 [GSM441943..GSM441951]: ChIP-chip of H3K27AC in L3 [GSM441984..GSM441992]: ChIP-chip of H3K27AC in Adult male [GSM441995..GSM442003]: ChIP-chip of H3K27AC in Pupae For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODEDataReleasePolicyFinal2008.pdf
2009-03-28 | GSE15430 | GEO
Project description:Epithelial ovarian cancer (EOC) represents the gynecologic cancer with the highest mortality rate. Despite a high initial response to chemotherapy, the majority of patients with advanced EOC relapses and subsequently develops chemoresistance that results in treatment failure and death of the patient. AIM: we have generated an isogenic model of PT-resistance in a panel of 3 EOC cell lines. microRNA profiling was used to identify new molecular pathway that regulate chemoresistance.
2017-07-24 | GSE93794 | GEO
Project description:Epithelial ovarian cancer (EOC) represents the gynecologic cancer with the highest mortality rate. Despite a high initial response to chemotherapy, the majority of patients with advanced EOC relapses and subsequently develops chemoresistance that results in treatment failure and death of the patient. AIM: we have generated an isogenic model of PT-resistance in a panel of 3 EOC cell lines. Gene Expression Profile (GEP) was used to identify new molecular pathawy that regulate chemoresistance.
2017-07-24 | GSE93793 | GEO
Project description:We report high-throughput profiling of acetylation of lysine 27 on histone H3 from whole zebrafish ventricles. The H3K27Ac mark has been shown to be present at active enhancer elements and including regions of active chromatin. We profile H3K27Ac in uninjured cardiomyocytes and those undergoing regeneration 14 days after genetic ablation. This study provides a framework for understanding chromatin transitions during adult models of regeneration.
2017-03-07 | GSE81863 | GEO