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In situ Hi-C profiles of DP thymocyltes from control and Suv39h1/Suv39h2 double knockout mice

ABSTRACT: H3K9me3-dependent heterochromatin is critical for the silencing of repeat-rich pericentromeric regions and also has key roles in repressing lineage-inappropriate protein-coding genes for healthy cellular function. Here we investigate the disruption of genome organization in the absence of H3K9me3-dependent heterochromatin by performing in situ Hi-C in primary immune cells deficient in both Suv39h1 and Suv39h2 (Suv39DKO), the major mammalian histone methyltransferase enzymes which catalyse heterochromatic H3K9me3 deposition.

ORGANISM(S): Mus musculus

PROVIDER: GSE156294 | GEO | 2024/03/27

REPOSITORIES: GEO

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Loss of H3K9 tri-methylation alters chromosome compaction and transcription factor retention during mitosis

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Loss of H3K9 tri-methylation alters mitotic chromosome compaction and transcription factor retention during mitosis

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