Stem cell-derived neutrophil-primed progenitors prevent lethal infection

ABSTRACT: We show that engineered neutrophil-primed progenitors derived from human induced pluripotent stem cells (NeuPs-XL) can produce functional neutrophil-like cells (NeuCs-XL) that can act promptly in vivo against lethal bacterial infections at a clinically applicable scale. We performed global gene expression profiling of NeuPs-XL and NeuCs-XL with or without LPS stimulation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE156612 | GEO | 2020/08/22

REPOSITORIES: GEO