Characterization of human non-hematopoietic bone marrow cells in non-fibrotic and fibrotic conditions

ABSTRACT: We isolated non-hematopoietic cells from fibrotic and non-fibrotic human bone marrow and perfomed scRNAseq on them. We identified 3 different stromal populations and 2 populations of hematopoietic progenitors. Our analysis revealed mesenchymal stromal cells (MSC) as pro-fibrotic cells. MSCs were functionally reprogrammed with loss of their progenitor status and acquisition of a pro-fibrotic phenotype in the fibrotic bone marrow. Additionally, stromal cells exhibited an upregulation of pro-inflammatory mediators like S100A8/A9.

ORGANISM(S): Homo sapiens

PROVIDER: GSE156640 | GEO | 2020/11/03

REPOSITORIES: GEO