Using high-density exon arrays to profile gene expression in closely related species (HJAY)

ABSTRACT: Global comparisons of gene expression profiles between species provide significant insight into gene regulation, evolutionary processes, and disease mechanisms. In this work, we describe a flexible and intuitive approach for global expression profiling of closely related species, using high-density exon arrays designed for a single reference genome. The high-density probe coverage of exon arrays allows us to select the identical set of perfect-match probes for measuring expression levels of orthologous genes. This eliminates a serious confounding factor in probe affinity effects of species-specific microarray probes, and enables direct comparisons of estimated expression indexes across species. Keywords: analysis of gene expression in tissues

ORGANISM(S): Homo sapiens Pan troglodytes Macaca mulatta

PROVIDER: GSE15665 | GEO | 2009/05/05

SECONDARY ACCESSION(S): PRJNA122927

REPOSITORIES: GEO