Transcriptomics

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Pan-Cancer Single Cell Landscape of Tumor-Infiltrating T Cells


ABSTRACT: T cells present diverse states in the tumor, playing a central role in cancer immunity and immunotherapies. However, their heterogeneity, dynamics and composition within tumors of various cancer types are not fully characterized. Integrating a pan-cancer single-cell RNA sequencing atlas of T cells cross multiple cancer types, we systematically characterized their diversity, identified the potentially tumor-reactive T cells, and revealed new cell types. Our findings provide new insights into T cell immunity and will facilitate immunotherapy development targeting T cells in human cancer.

ORGANISM(S): Homo sapiens

PROVIDER: GSE156728 | GEO | 2021/12/16

REPOSITORIES: GEO

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