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Genome-wide transcriptomic analysis of MRTF-active subpopulations in naïve human basal cell carcinoma

ABSTRACT: Tumor heterogeneity and lack of knowledge about resistant cell states remain a significant barrier to effective targeted cancer therapies. Basal cell carcinomas (BCCs) uniformly depend on Hedgehog (Hh)/Gli signaling for cell growth. We previously identified a nuclear myocardin-related transcription factor (nMRTF) resistance pathway that amplifies Gli1 activity, but nMRTF cell state and key factors driving its accumulation remain unknown. Here, we use three surface markers (LYPD3, TACSTD2, and LY6D) to isolate the nMRTF subpopulation and analyze transcriptomic profiles.

ORGANISM(S): Homo sapiens

PROVIDER: GSE156790 | GEO | 2020/08/25

REPOSITORIES: GEO

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