Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress

ABSTRACT: Here we report Total RNA seq and RiboSeq on MEF cells treated with halofuginone. Halofuginone is a competitive inhibitor of the Prolyl-tRNA synthetase that results in an accumulation of uncharged Prolyl-tRNA upon treatment that leads to an activation of the protein kinase Gcn2.

ORGANISM(S): Mus musculus

PROVIDER: GSE156850 | GEO | 2021/05/26

REPOSITORIES: GEO