Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

P53 activation during ribosome biogenesis regulates normal erythroid differentiation.

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE157210 | GEO | 2020/09/14

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

p53 activation during ribosome biogenesis regulates normal erythroid differentiation. [expression]

Project description:The role of ribosome biogenesis in erythroid development is supported by the recognition of erythroid defects in ribosomopathies in both Diamond-Blackfan anemia and 5q- syndrome. Whether ribosome biogenesis exerts a regulatory function on normal erythroid development is still unknown. In the present study, a detailed characterization of ribosome biogenesis dynamics during human and murine erythropoiesis shows that ribosome biogenesis is abruptly interrupted by the drop of rDNA transcription and the collapse of ribosomal protein neo-synthesis. Its premature arrest by RNA polI inhibitor, CX-5461 targets the proliferation of immature erythroblasts. We also show that p53 is activated spontaneously or in response to CX-5461 concomitantly to ribosome biogenesis arrest, and drives a transcriptional program in which genes involved in cell cycle arrest, negative regulation of apoptosis and DNA damage response were upregulated. RNA polI transcriptional stress results in nucleolar disruption and activation of ATR-CHK1-p53 pathway. Our results imply that the timing of ribosome biogenesis extinction and p53 activation are crucial for erythroid development. In ribosomopathies in which ribosome availability is altered by unbalanced production of ribosomal proteins, the threshold of ribosome biogenesis down-regulation could be prematurely reached and together with pathological p53 activation prevents a normal expansion of erythroid progenitors.

2020-09-14 | GSE137951 | GEO

p53 activation during ribosome biogenesis regulates normal erythroid differentiation. [ChIP-Seq]

2020-09-14 | GSE157208 | GEO

p53 activation during ribosome biogenesis regulates normal erythroid differentiation.

Project description:p53 activation during ribosome biogenesis regulates normal erythroid differentiation.

| PRJNA660448 | ENA

p53 activation during ribosome biogenesis regulates normal erythroid differentiation. [expression]

Project description:p53 activation during ribosome biogenesis regulates normal erythroid differentiation. [expression]

| PRJNA573943 | ENA

p53 activation during ribosome biogenesis regulates normal erythroid differentiation. [ChIP-Seq]

Project description:p53 activation during ribosome biogenesis regulates normal erythroid differentiation. [ChIP-Seq]

| PRJNA660447 | ENA

Bmi1 promotes erythroid development through regulating ribosome biogenesis.

Project description: Not available

| S-EPMC4380436 | biostudies-literature

Post-transcriptional regulation of Ribosome Biogenesis during differentiation

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-08-03 | GSE214875 | GEO

Ldb1 regulates carbonic anhydrase 1 during erythroid differentiation.

Project description: Not available

| S-EPMC3720789 | biostudies-literature

Atf4 promotes erythroid differentiation by regulating ribosome biogenesis via RPS19BP1

Project description:To elucidate the mechanisms underlying the role of Atf4 deficiency in erythropoiesis, we performed 10X Genomics single-cell RNA sequencing on Lin-cKit+ cells from Atf4 hematopoietic cell-specific conditional knockout mice (KO) and Atf4 floxed mice (WT) at steady state (referred to KO_BM and WT_BM) and after secondary transplantation (referred to cKO_t and WT_t). Furthermore, we also sorted CMP cells from Atf4 hematopoietic cell-specific conditional knockout mice (KO) and ATF4 floxed mice (WT) for 10X Genomics scRNA-seq.

2024-03-15 | GSE235798 | GEO

GATA-1 directly regulates p21 gene expression during erythroid differentiation.

Project description: Not available

| S-EPMC3019278 | biostudies-literature