Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Myosin 7b is a regulatory long noncoding RNA (lncMYH7b) in the human heart

ABSTRACT: We have discovered that the alternative splice form of MYH7b is a regulatory non-coding RNA in the human heart. This dataset contains manipulation of levels of lncMYH7b in human cardiomyocytes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE157217 | GEO | 2020/09/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Myosin 7b is a regulatory long noncoding RNA (lncMYH7b) in the human heart [adenovirus either expressing GFP or MYH7b_sp]

Project description:We have discovered that the alternative splice form of MYH7b is a regulatory non-coding RNA in the human heart. This dataset contains a forced expression of a peptide encoded by a short ORF at the beginning of the alternate splice form (MYH7b_sp) in cardiomyocytes.

2020-09-02 | GSE157260 | GEO

Myosin 7b is a regulatory long noncoding RNA (lncMYH7b) in the human heart.

Project description: Not available

| S-EPMC8141895 | biostudies-literature

Myosin 7b is a regulatory long noncoding RNA (lncMYH7b) in the human heart

Project description:Myosin 7b is a regulatory long noncoding RNA (lncMYH7b) in the human heart

| PRJNA660456 | ENA

Expression of Normally Repressed Myosin Heavy Chain 7b in the Mammalian Heart Induces Dilated Cardiomyopathy.

Project description: Not available

| S-EPMC6761648 | biostudies-literature

The long noncoding RNA Caren protects against heart failure via suppressing the Hint1-ATM signaling pathway

Project description:Long noncoding RNAs (lncRNAs) have potential as novel therapeutic targets in cardiac disease, but their function in heart failure (HF) is not yet fully understood. Using a gene trapping approach in mouse embryonic stem cells, we identified a novel cytoplasmic lncRNA, dubbed Caren (cardiomyocyte-enriched noncoding transcript), which was predominantly expressed in cardiomyocytes. Caren was markedly downregulated in the mouse failing heart that was subjected to transverse aortic constriction (TAC). The ablation of Caren in the mouse heart accelerated HF-related phenotypes by TAC, whereas mice overexpressing Caren (CAG-Caren Tg mice) resisted TAC-induced HF. Proteomic analysis identified histidine triad nucleotide-binding protein 1 (Hint1) as a Caren target protein, while bioinformatic analysis of proteome revealed that Caren regulates the proteins involved in mitochondrial energetics in the heart. Furthermore, we found that Caren suppressed Hint1 expression at the translational level and that Hint1 overexpression reduced mitochondrial respiration capacity. Similar to CAG-Caren Tg mice, the reduced Hint1 expression in mice exerted cardioprotective effects on TAC-induced HF, which was associated with the decreased level of ATM serine/threonine kinase phosphorylation, known to activate DNA damage responses. Overall, we identify a novel cytoplasmic lncRNA that protects against the development of HF through suppressing the Hint1-ATM signaling, which presumably maintains mitochondrial energetics and prevents the DNA damage under pathological stress.

2021-02-08 | PXD016186 | Pride

Long noncoding RNA dysregulation in ischemic heart failure.

Project description: Not available

| S-EPMC4912721 | biostudies-literature

Myosin 7b is a regulatory long noncoding RNA (lncMYH7b) in the human heart [adenovirus either expressing GFP or MYH7b_sp]

Project description:Myosin 7b is a regulatory long noncoding RNA (lncMYH7b) in the human heart [adenovirus either expressing GFP or MYH7b_sp]

| PRJNA660664 | ENA

Myosin-7b Promotes Distal Tip Localization of the Intermicrovillar Adhesion Complex.

Project description: Not available

| S-EPMC5117816 | biostudies-literature

Right ventricular long noncoding RNA expression in human heart failure.

Project description: Not available