Dataset Information


Gene expression data from spleen, cervical spinal cord, and thalamic regions of ME7-inoculated mouse

ABSTRACT: An essential and remarkable process of the biochemical and physiological features in prion diseases is the conversion of a host-encoded prion protein (PrPC) into a misfolded isoform (PrPSc). The conversion of PrPC and the replication of prions, in cases of peripheral infection, occur following the uptake and subsequent spread of prions to brain via spinal cord. We investigated the changes of gene expression profiles in the spleen, cervical spinal cord and thalamus following intraperitoneal inoculation of ME7 scrapie prion and the inter-tissue alterations of the differentially expressed genes through Venn diagram to find genes which are commonly influenced by ME7 scrapie prion spread in the three tissues. Overall design: C57BL/6 mice were divided into two experimental groups; C: Control, ME7: intraperitoneally ME7-inoculated. At the terminal stage (270 ± 8 days after the clinical signs are evident) of ME7 scrapie prion disease total RNA was isolated from three tissue regions of two experimental group (2 experimental group × 3 tissue samples of each experimental group × 2 mice = total 12 samples).

INSTRUMENT(S): [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]

ORGANISM(S): Mus musculus  

SUBMITTER: Yeong-Gon Choi  

PROVIDER: GSE157334 | GEO | 2021-12-31


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