Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-cell B receptor VDJ sequencing from HGSOC isolated B cells

ABSTRACT: Purpose: Evaluation of the BCR profile of HGSOC associated/infiltrated B cells

ORGANISM(S): Homo sapiens

PROVIDER: GSE157429 | GEO | 2020/11/24

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Single-cell RNA/ATAC multiomic analysis of TRM and ReCirulating CD8+ T cells from HGSOC tumors

Project description:Purpose: Evaluation of the BCR profile of HGSOC associated/infiltrated B cells

2022-03-07 | GSE192780 | GEO

Single-cell B receptor VDJ sequencing from HGSOC isolated B cells

Project description:Single-cell B receptor VDJ sequencing from HGSOC isolated B cells

| PRJNA661287 | ENA

single-cell RNA and TCR sequencing of TRM CD8+ T cells sorted from 8 HGSOC tumors

Project description:Purpose: Characterization of the gene expression profile and TCR profile of CD8+ TILs (TRM and re-circulating) from HGSOC to understand the immunogenicity of ovarian cancer

2022-03-07 | GSE194105 | GEO

single-cell RNA and TCR sequencing of TRM and ReCirulating CD8+ T cells sorted from 4 HGSOC tumors

Project description:Purpose: Characterization of the gene expression profile and TCR profile of CD8+ TILs (TRM and re-circulating) from HGSOC to understand the immunogenicity of ovarian cancer

2022-03-07 | GSE193371 | GEO

RNA-seq of FFPE-macrodissected HGSOC tissues and solid and ascites-derived HGSOC 2D cultures

Project description:Stratification of a retrospective cohort of HGSOC based on its tissues of origin.

2020-09-29 | E-MTAB-9605 | biostudies-arrayexpress

Bulk RNA sequencing of TRM and ReCirculating CD8+ T cells from 7 HGSOC tumors

Project description:Purpose: Characterization of the gene expression profile of CD8+ TILs (TRM vs. re-circulating) from 7 HGSOC

2022-03-07 | GSE194383 | GEO

RNA-seq of isolated tumor cells from high grade serous ovarian cancer (HGSOC) patients

Project description:Tumor cells were isolated from solid tumors or ascites from HGSOC patients and enriched for EpCAM expression by antibody magnetic beads (affinity)-based methods and large RNAs (> 200 nt) sequenced (50 bp paired ends) after rRNA depletion (RiboZero). Expression differences between patients with miliary and non-miliary peritoneal tumor spreading were used for a search for new targeted therapies and for biological annotion.

2020-01-01 | E-MTAB-7674 | biostudies-arrayexpress

Single-cell RNA sequencing samples from high-grade serous ovarian cancer (HGSOC)

Project description:We measured gene expression in single-cell RNA sequencing samples from patients with high-grade serous ovarian cancer (HGSOC), for a study on improving HGSOC subtype definition by taking into account varying cell type proportions within tumors.

2020-10-03 | GSE158937 | GEO

RNA-seq of FFPE-macrodissected HGSOC tissues and solid and ascites-derived HGSOC 2D cultures

Project description:RNA-seq of FFPE-macrodissected HGSOC tissues and solid and ascites-derived HGSOC 2D cultures

| PRJEB40519 | ENA

Single cell RNA-seq of hemagglutinin specific B cells after influenza virus infection: VDJ data

Project description:Understanding dynamics of antigen specific B cell responses and link between BCR and B cell differentiation is crucial for our ability to direct immune responses and to generate memory and plasma cells responses to protective targets. Here we have infected mice with IAV-PR8 and sacrificed them at different days after infection (7-14-28). 2 naive mice were used as controls (spleen and lungs). From individual spleen, lungs and mediastinal lymph nodes we have sorted Hemagglutinin (HA)-specific IgD- B cells and single cell sequenced RNA and BCR. We identify several known and novel B cell subpopulations forming after infection and find organ-specific difference that persist over the course of the response. We found important transcriptional differences between memory cells in lungs and immune organs and describe organ-restricted clonal expansion. Strikingly, by combining BCR mutational analysis, monoclonal antibody expression and affinity measurements we found no differences between germinal center (GC)-derived memory and plasma cells, at odds with an affinity-based selection model. These finding provide the most comprehensive picture to date of organ specific antiviral B cell responses, differentiation, clonal-proliferation and dynamics.

2021-06-22 | E-MTAB-9478 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data