Tet2-mediated epigenetic modifications during aging of hematopoietic stem and progenitor cells

ABSTRACT: we compared self-renewal and lineage specification of WT and Tet2-deficient HSPCs during ageing and demonstrated that Tet2 ablation alters age-dependent HSC functional decline, revealing a disparate ageing process in the Tet2-deficient haemopoietic system.

ORGANISM(S): Mus musculus

PROVIDER: GSE157592 | GEO | 2023/09/10

REPOSITORIES: GEO