Transcriptomics,Genomics

Dataset Information

25

Profiling of the response of genes in the rat liver to hepatotoxicants


ABSTRACT: This data set comprises of the standardized experimental design for the microarray gene expression data derived from the rat liver (target tissue) after treatment with eight known hepatotoxicants (at multiple time points and doses with multiple biological replicates and a fluor-flip for each biological sample). Overall design: We analyzed the gene expression data from the livers of F344/N male rats 10-12 weeks of age exposed for 6, 24 or 48 hrs to a low, medium or high dose of one of eight hepatotoxicants.

INSTRUMENT(S): Agilent-011868_D_WithSGCtrls_20030627 Rat Oligo Microarray

SUBMITTER: Pierre Robert Bushel  

PROVIDER: GSE15785 | GEO | 2009-04-28

SECONDARY ACCESSION(S): PRJNA116861

REPOSITORIES: GEO

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This report details the standardized experimental design and the different data streams that were collected (histopathology, clinical chemistry, hematology and gene expression from the target tissue (liver) and a bio-available tissue (blood)) after treatment with eight known hepatotoxicants (at multiple time points and doses with multiple biological replicates). The results of the study demonstrate the classification of histopathological differences, likely reflecting differences in mechanisms o  ...[more]

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