Captopril treatment in rats with DEN-induced cirrhosis and hepatocellular carcinoma

ABSTRACT: Hepatocellular carcinoma (HCC) is one of the leading cause of cancer-related mortality worldwide. Liver cirrhosis is well-established risk factor of HCC development, although prevention of HCC in cirrhosis patients is challenging. By utilizing bioinformatic compound screening based on a clinical HCC-risk-predicitve gene signature, we identified captopril as a potential HCC chemoprevention agent. We tested the drug in rats with diethylnitrosamine (DEN)-induced cirrhosis and HCC, and confirmed its HCC-preventive effect.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE157919 | GEO | 2022/08/02

REPOSITORIES: GEO