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Transcriptional analysis of MC38 colorectal tumor cells sorted from mice fed high-fat or control diet

ABSTRACT: Examination of transcriptional changes associated with diet-induced obesity in syngeneic MC38 tumors.

ORGANISM(S): Mus musculus

PROVIDER: GSE157994 | GEO | 2020/12/15

REPOSITORIES: GEO

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Transcriptional analysis of CD45+ leukocytes isolated from syngeneic MC38 tumors from mice fed high-fat or control diet

Project description:Examination of transcriptional changes associated with diet-induced obesity in tumor-infiltrating CD45+ leukocytes from syngeneic MC38 colorectal tumors.

2020-12-15 | GSE157990 | GEO

Transcriptional analysis of CD8+ T lymphocytes isolated from syngeneic MC38 tumors and tumor-draining lymph nodes from mice fed high-fat or control diet

Project description:Examination of transcriptional changes associated with diet-induced obesity in CD8+ T lymphocytes that infiltrate syngeneic MC38 tumors.

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TMT-proteomics of sorted MC38+ tumor cells with high-fat diet

Project description:Obesity is a major cancer risk factor, but the underlying molecular mechanisms are not always known. In this study, we look at proteome remodeling in cancer cells with obesity, comparing tumor cells sorted from mice fed high-fat versus control diet. We conducted 10-plex TMT-proteomics on GFP+ MC38 colorectal adenocarcinoma tumor cells, sorted from subcutaneously implanted tumors 12 days after implantation. This study reveals molecular pathways that change in cancer cells with obesity that promote tumor growth.

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Transcriptional analysis of MC38 colorectal tumor cells sorted from mice fed high-fat or control diet

Project description:Transcriptional analysis of MC38 colorectal tumor cells sorted from mice fed high-fat or control diet

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MC38 tumors from mice fed high-fat or control diet

Project description:MC38 tumors from mice fed high-fat or control diet

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Microarray of MC38-R tumors following intratumoral injection of IL-12 mRNA or control mRNA

Project description:We designed a novel intratumoral (IT) IL-12 mRNA therapy to promote local IL-12 tumor production whilst mitigating systemic effects. A single IT dose of mouse (m)IL-12 mRNA induced IFNγ and CD8+ T cell-dependent tumor regression in multiple syngeneic mouse models including MC38-R, and animals with a complete response demonstrated immunity to re-challenge. In order to further investigate the impact of mIL-12 mRNA on the MC38-R TME, we performed tumor transcriptomic evaluation 24h and 7 days after a single IT dose of 0.5 micrograms IL-12 or control mRNA. mRNA was isolated from snap-frozen syngeneic tumors using an RNeasy mini kit (Qiagen) and quantified on the Affymetrix mouse 430 2.0 microarray.

2020-09-01 | E-MTAB-9316 | biostudies-arrayexpress

Transcriptional analysis of CD45+ leukocytes isolated from syngeneic MC38 tumors from mice fed high-fat or control diet

Project description:Transcriptional analysis of CD45+ leukocytes isolated from syngeneic MC38 tumors from mice fed high-fat or control diet

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MC38 tumors from mice fed high-fat or control diet

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-12-15 | GSE157999 | GEO

Expression data from murine colorectal tumors of mice fed a normal chow diet and a high fat diet

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