Transcriptomics,Genomics

Dataset Information

37

The global responses of human bone marrow-derived mesenchymal stem cells to baculovirus transduction


ABSTRACT: Human mesenchymal stem cells (hMSCs) are a promising cell source for regenerative medicine and can be genetically modified with viral vectors, yet how hMSCs respond to viral vector transduction remains poorly understood, leaving the safety concerns unaddressed. Hereby we explored the responses of hMSCs against an emerging DNA viral vector, baculovirus (BV), and uncovered that BV transduction perturbed the transcription of 816 known genes associated with several signaling pathways. Overall design: Both experimental group (e.g. BV-transduced hMSCs) and control group (e.g. mock-transduced hMSCs) have four replicates respectively.

INSTRUMENT(S): Phalanx Human OneArray

SUBMITTER: Yu-Chen Hu  

PROVIDER: GSE15810 | GEO | 2009-04-30

SECONDARY ACCESSION(S): PRJNA116723

REPOSITORIES: GEO

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Publications

Baculovirus transduction of mesenchymal stem cells triggers the toll-like receptor 3 pathway.

Chen Guan-Yu GY   Shiah Hsiao-Chiao HC   Su Hung-Ju HJ   Chen Chi-Yuan CY   Chuang Yung-Jen YJ   Lo Wen-Hsin WH   Huang Jie-Len JL   Chuang Ching-Kuang CK   Hwang Shiaw-Min SM   Hu Yu-Chen YC  

Journal of virology 20090805 20


Human mesenchymal stem cells (hMSCs) can be genetically modified with viral vectors and hold promise as a cell source for regenerative medicine, yet how hMSCs respond to viral vector transduction remains poorly understood, leaving the safety concerns unaddressed. Here, we explored the responses of hMSCs against an emerging DNA viral vector, baculovirus (BV), and discovered that BV transduction perturbed the transcription of 816 genes associated with five signaling pathways. Surprisingly, Toll-li  ...[more]

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