Chemical Inhibition of H3K27me3 demethylases during B cell differentiation

ABSTRACT: To understand the role of the H3K27me3 demethylases, UTX and JMJD3, in B cell differentiation. Naïve B cells were cultures ex vivo with LPS, IL-2,IL-5 in the presence of DMSO or GSK-J4, UTX/JMJD3 inhibitor. Plasmablasts and activated B cells were magnetically enriched after 3 days of culture.

ORGANISM(S): Mus musculus

PROVIDER: GSE158139 | GEO | 2021/11/16

REPOSITORIES: GEO