Transcriptomics

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Effects of maoto (ma-huang-tang) on transcriptome signature in influenza virus infection

ABSTRACT: We evaluated the effects of maoto, a traditional kampo medicine, as a herbal multi-compound medicine on host transcriptome responses in a mouse model of influenza infection. On the fifth day of oral administration to mice intranasally infected with influenza virus (A/PR/8/34 (H1N1), maoto significantly improved survival rate, decreased viral titer, and ameliorated the infection-induced phenotype as compared with control mice. Analysis of the lung and plasma transcriptome profile showed that maoto significantly up-regulated the expression of macrophage- and T-cell-related genes. Collectively, these results suggest that maoto regulates the host’s inflammatory response.

ORGANISM(S): Mus musculus

PROVIDER: GSE158270 | GEO | 2021/10/21

REPOSITORIES: GEO

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