Alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19

ABSTRACT: To characterize the early immune responses against coronavirus infection, we infected rhesus macaques and hACE2 transgenic mice with SARS-CoV-2 and analyzed the transcriptome of infected and non-infected animals. We infected WT mice with IAV as a normal respiratory virus group. During analysis, we found that S100A8 was dramatically upregulated by SARS-CoV-2 and a mouse coronavirus (mouse hepatitis virus, MHV), but not by other tested viruses. A group of non-canonical neutrophils were also activated during SARS-CoV-2 infection.

ORGANISM(S): Mus musculus Macaca mulatta

PROVIDER: GSE158297 | GEO | 2021/01/19

REPOSITORIES: GEO