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Mutant SETBP1 enhances NRAS-driven MAPK pathway activation to promote aggressive leukemia

ABSTRACT: Mutations in SET binding protein 1 (SETBP1) are associated with poor outcomes in myeloid leukemias. In the Ras-driven leukemia, juvenile myelomonocytic leukemia, SETBP1 mutations are enriched in relapsed disease. We demonstrate that SETBP1 enhances the NRAS gene expression signature, driving upregulation of mitogen-activated protein kinase (MAPK) signaling and downregulation of differentiation pathways.

ORGANISM(S): Mus musculus

PROVIDER: GSE158379 | GEO | 2021/05/18

REPOSITORIES: GEO

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