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Differentially expressed lncRNA in biological premature ovarian insufficient(bPOI)

ABSTRACT: We have completed the lncRNA expression profiling of human granulosa cells to reveals the differentially expressed lncRNAs involved in POI.

ORGANISM(S): Homo sapiens

PROVIDER: GSE158526 | GEO | 2021/02/20

REPOSITORIES: GEO

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Differentially expressed mRNA in biological premature ovarian insufficient (bPOI)

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Project description:Premature ovarian insufficiency (POI) is a disease featured by early menopause before 40 years of age, accompanied by an elevation of follicle-stimulating hormone (FSH). Though POI affects many aspects of women’s health, its major causes remain unknown. Many clinical studies have shown that POI patients are generally underweight, indicating a potential correlation between POI and metabolic disorders. To understand the pathogenesis of POI, we performed metabolomics analysis on serum and identified branch chain amino acid (BCAA) insufficiency related metabolic disorders in two independent cohorts from two clinics. A low BCAA diet phenotypically reproduced the metabolic, endocrine, ovarian, and reproductive changes of POI in young C57 B6 mice. A mechanism study revealed that the BCAA insufficiency induced POI is associated with abnormal activation of the ceramide-ROS axis and consequent impairment of ovarian granulosa cell function. Significantly, dietary supplement of BCAA prevented the development of ROS-induced POI in female mice. The results of this pathogenic study will lead to the development of specific therapies for POI.

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