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Specific and behaviorally consequential astrocyte G q GPCR signaling attenuation in vivo with iβARK

ABSTRACT: The Khakh laboratory used astrocyte selective AAVs expressing Rpl22-HA along with bARK for attenuating Gq pathway signaling in the dorsal striatum. In the control group, bARK(D110A), which is a mutated control of bARK was expressed instead of bARK. The mouse striatum expressing either bARK or bARK(D110A) was subjected to RNA-seq in order to compare striatal astrocyte transcriptomes with and without Gq-GPCR signaling attenuation.

ORGANISM(S): Mus musculus

PROVIDER: GSE158876 | GEO | 2021/09/30

REPOSITORIES: GEO

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