To identify GCM1 novel target genes by chromatin immunoprecipitation-on-chip (ChIP-chip) analysis

ABSTRACT: In this study, we performed chromatin immunoprecipitation-on-chip (ChIP-chip) analysis and identified the gene for high-temperature requirement protein A4 (HtrA4) as a GCM1 target gene, which encodes a serine protease facilitating cleavage of fibronectin and invasion of placental cells. Importantly, HtrA4 is immunolocalized in EVTs at the maternal-fetal interface, and its expression is decreased by hypoxia and in preeclampsia, a pregnancy complication associated with placental hypoxia and shallow trophoblast invasion.

ORGANISM(S): Homo sapiens

PROVIDER: GSE158894 | GEO | 2021/06/11

REPOSITORIES: GEO