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Oxidative stress alters transcript localization of disease-causing genes in the retinal pigment epithelium

ABSTRACT: To evaluate the effect of oxidative stress on transcript localization in the retinal pigment epithelium (RPE), we performed poly-A RNA sequencing on nuclear and cytoplasmic fractions from induced pluripotent stem cell-derived retinal pigment epithelium (iPSC-RPE) cells exposed to hydrogen peroxide, as well as untreated controls.

ORGANISM(S): Homo sapiens

PROVIDER: GSE158909 | GEO | 2022/06/23

REPOSITORIES: GEO

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