Comprehensive methylome sequencing reveals prognostic epigenetic biomarkers for prostate cancer mortality

ABSTRACT: We profiled DNA from primary tumour RP tissue specimens from 15 patients (and adjacent normal tissue specimens from 4 patients) in a discovery cohort using whole-genome bisulphite sequencing (WGBS). We identified a set of differentially methylated regions in the primary tumour samples between patients who died ≤ 10 yrs post-RP and those still alive > 10 yrs post RP (median follow-up time: 19.5 years).

ORGANISM(S): Homo sapiens

PROVIDER: GSE158927 | GEO | 2022/10/03

REPOSITORIES: GEO