Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

An early cortical progenitor-specific mechanism regulates thalamocortical innervation

ABSTRACT: Comparison of the wild-type subplate transcriptome with that of the Emx1Cre11.5;Lhx2lox/lox and NexCre;Lhx2lox/lox subplate and further analysis of differentially expressed genes that were specific to the Emx1Cre11.5;Lhx2lox/lox dataset

ORGANISM(S): Mus musculus

PROVIDER: GSE159006 | GEO | 2023/09/25

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

An Early Cortical Progenitor-Specific Mechanism Regulates Thalamocortical Innervation.

Project description: Not available

| S-EPMC8360687 | biostudies-literature

An early cortical progenitor-specific mechanism regulates thalamocortical innervation

Project description:An early cortical progenitor-specific mechanism regulates thalamocortical innervation

| PRJNA667339 | ENA

Postnatal day 3 (P3) mouse cortical projection neurons: Ctrl versus Cdk7 KO

Project description:Transcriptional profiling of primary Cdk7 KO mouse cortical projection neurons compared to Ctrl neurons. Samples were obtained by FACS sorting EYFP+ cells from postnatal day 3 (P3) NexCre/+;Cdk7lox/lox, R26EYFP/+ (Cdk7 KO) and NexCre/+;Cdk7+/+, R26EYFP/+ (Ctrl) mouse cortices. Goal was to determine the effects of Cdk7 elimination on gene transcription in developing cortical projection neurons.

2026-07-15 | GSE314177 | GEO

Activity-induced gene expression and long-range enhancer-promoter contacts in cohesin-deficient neurons (Ribo Tag)

Project description:RNA-seq of ribosome associated mRNA from Rad21lox/lox;NexCre/+;RiboTag+ and Rad21+/+;NexCre/+;RiboTag+ dissociated cortical neurons at Day In Vitro (DIV10)

2022-04-26 | GSE172428 | GEO

Activity-induced gene expression and long-range enhancer-promoter contacts in cohesin-deficient neurons (NexCre)

Project description:RNA-seq of total RNA from Rad21lox/lox;NexCre/+ and Rad21+/+;NexCre/+ dissociated cortical neurons at Day In Vitro (DIV10) without stimulation or after treatment with TTX/D-AP5 and 1h or 6h of KCl depolarization.

2022-04-26 | GSE172427 | GEO

Reliance of neuronal gene expression on cohesin scales with chromatin loop length (5C)

Project description:5C-seq from Rad21lox/lox;NexCre/+ and Rad21+/+;NexCre/+ dissociated cortical neurons at Day In Vitro (DIV10) without stimulation or after treatment with TTX/D-AP5 and 1h of KCl depolarization. And, 5C of and doxycycline treated Rad21-TEV primary neurons transduced with NLS-TEV

2024-04-16 | GSE194197 | GEO

Chromatin remodeler Arid1a regulates subplate neuron identity and wiring of cortical connectivity

Project description:Loss-of-function mutations in chromatin remodeler gene ARID1A are a cause of Coffin-Siris syndrome, a developmental disorder characterized by dysgenesis of corpus callosum. Here, we characterize Arid1a function during cortical development and find unexpectedly selective roles for Arid1a in subplate neurons. Subplate neurons (SPNs), strategically positioned at the interface of cortical grey and white matter, orchestrate multiple developmental processes indispensable for neural circuit wiring. We find that pan-cortical deletion of Arid1a leads to extensive mistargeting of intracortical axons and agenesis of corpus callosum. Sparse Arid1a deletion, however, does not autonomously misroute callosal axons, implicating non-cell autonomous Arid1a functions in axon guidance. Supporting this possibility, the ascending axons of thalamocortical neurons, which are not autonomously affected by cortical Arid1a deletion, are also disrupted in their pathfinding into cortex and innervation of whisker barrels. Coincident with these miswiring phenotypes, which are reminiscent of subplate ablation, we unbiasedly find a selective loss of SPN gene expression following Arid1a deletion. In addition, multiple characteristics of SPNs crucial to their wiring functions, including subplate organization, subplate-thalamocortical axon co-fasciculation (“handshake”), and extracellular matrix, are severely disrupted. To empirically test Arid1a sufficiency in subplate, we generate a cortical plate deletion of Arid1a that spares SPNs. In this model, subplate Arid1a expression is sufficient for subplate-thalamocortical axon co-fasciculation and extracellular matrix assembly. Consistent with these wiring functions, subplate Arid1a sufficiently enables normal callosum formation, thalamocortical axon targeting, and whisker barrel development. Thus, Arid1a is a multifunctional regulator of subplate-dependent guidance mechanisms essential to cortical circuit wiring.

2021-05-06 | GSE163273 | GEO

Higher-order thalamocortical circuits are specified by embryonic cortical progenitor types in the mouse brain.

Project description: Not available

| S-EPMC7617957 | biostudies-literature

Convergent cortical innervation of striatal projection neurons.

Project description: Not available

| S-EPMC4085670 | biostudies-literature

Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis.

Project description: Not available

| S-EPMC3376907 | biostudies-literature