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Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology

ABSTRACT: Neural progenitors derived from human pluripotent stem cells (hPSCs) develop into electrophysiologically active neurons at heterogeneous rates, which can confound disease-relevant discoveries in neurology and psychiatry. The goal of this study was to resolve the diversity of functional states of hPSC-derived neurons in vitro by combining patch clamping with morphological and RNA-sequencing analysis of single neurons (Patch-seq).

ORGANISM(S): Homo sapiens

PROVIDER: GSE159074 | GEO | 2020/10/07

REPOSITORIES: GEO

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