Effect of histone H2Av depletion on temperature dependence of the Drosophila S2R+ cell transcriptome

ABSTRACT: The histone H2A variant H2A.Z has a crucial role in the regulation of temperature-dependent gene expression in the plant Arabidopsis thaliana. To evaluate whether the Drosophila homolog histone H2Av has a similar role in the control of the transcriptional response to temperature change, we depleted this histone variant by RNA interference in S2R+ cells and analyzed the effect on the transcriptome after temperature shifts to different temperatures (14, 25 and 30°C). For control, we performed analogous experiments using treatment with lacZ dsRNA instead of His2Av dsRNA.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE159171 | GEO | 2021/09/13

REPOSITORIES: GEO