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Ints11 is essential for normal function of hematopoietic stem/progenitor cells [RNA-seq]

ABSTRACT: To investigate the role of INTS11 in normal hematopoiesis, Ints11 conditional KO mouse model was generated. We purified the Lin-cKit+ cells from bone marrow of WT and Ints11 KO mice and studied the differentially expressed genes due to the Ints11 loss.

ORGANISM(S): Mus musculus

PROVIDER: GSE159403 | GEO | 2021/09/22

REPOSITORIES: GEO

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Ints11 is essential for normal function of hematopoietic stem/progenitor cells [ChIP-Seq]

Project description:To investigate the role of INTS11 in normal hematopoiesis, Ints11 conditional KO mouse model was generated. We purified the Lin-cKit+ cells from bone marrow of WT and Ints11 KO mice and performed the ChIP-seq using different histone modifications to invesigate the gene regulation.

2021-09-22 | GSE159402 | GEO

Ints11 is essential for normal function of hematopoietic stem/progenitor cells [single-cell RNA-seq]

Project description:To investigate the role of INTS11 in normal hematopoiesis, Ints11 conditional KO mouse model was generated. We purified the cKit+ cells from bone marrow of WT and Ints11 KO mice and performed the single cell RNA-seq to study the molecular changes in each cell population.

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Bromodomain member BRD4 is required for hematopoietic stem cell functions (RNA-Seq)

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Bromodomain member BRD4 is required for hematopoietic stem cell functions (CUT&RUN)

Project description:To investigate the role of BRD4 in normal hematopoiesis, Brd4 conditional KO mouse model was generated. We purified the Lin-cKit+ cells from bone marrow of WT and Brd4 KO mice and performed the CUT&RUN to study the histone modification and Brd4 occupancy around genome in HSC/HPCs population.

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Gene-expression changes resulting from loss of the mTORC1 component Raptor in murine hematopoietic stem and progenitor cell-enriched populations (HSPC)

Project description:We investigated the role of mTORC1 in murine hematopoiesis by conditionally deleting the Raptor gene in murine hematopoietic stem cells. We observed mutliple alterations evoked by Raptor loss in hematopoiesis and profiled gene-expression alterations induced by raptor loss in Flt3-Lin-Sca1+cKit+ hematopoietic stem and progenitor enriched cell populations, 5 weeks post Raptor deletion. Flt3-Lin-Sca1+cKit+ cells were flow sorted from mice containing homozygous floxed alleles for exon 6 of the Raptor gene in the presence (MT group) or absence (WT group) of the MxCre transgene, which was induced with injections of mice with pIpC 5 weeks before cell isolation.

2012-09-19 | E-GEOD-32265 | biostudies-arrayexpress

Bromodomain member BRD4 is required for hematopoietic stem cell functions (scRNA-Seq)

Project description:To investigate the role of BRD4 in normal hematopoiesis, Brd4 conditional KO mouse model was generated. We purified the cKit+ and LSK cells from bone marrow of WT and Brd4 KO mice and performed the single cell RNA-seq to study the molecular changes in each cell population.

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Ints11 is essential for normal function of hematopoietic stem/progenitor cells

Project description:Ints11 is essential for normal function of hematopoietic stem/progenitor cells

| PRJNA668784 | ENA

Geminin regulates self-renewal and fate commitment decisions in fetal hematopoietic stem cells.

Project description:Conditional deletion of Geminin from the entire hematopoietic compartment using Vav1:iCre mice led to defective hematopoiesis/dyserythropoiesis in E15.5 mouse embryos. The present data set includes data from lineage-negative cells isolated from homogenized livers that were dissected from E15.5.dpc embryos. The two conditions compared were wild-type versus Geminin-KO Lin- cells. The cells were collected from littermates. Six samples were analyzed: three samples from each wild-type and Geminin-KO Lin- cells. For our analyses, we set cutoff values FC>1.5 and p-value <0.05. The analysis was carried out using the genotype criterion, but non-averaged for the three biological replicates.

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