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A whole-genome CRISPRa screening metformin resistance related gene in prostate cancer

ABSTRACT: Metformin is a classic type II diabetes drug which has possessed anti-tumor properties for various cancers. However, different cancers do not respond to metformin with the same effectiveness or acquire resistance. Thus, searching for vulnerabilities of metformin-resistant prostate cancer is a promising strategy to improve the therapeutic efficiency. A genome-scale CRISPR-Cas9 activation library targeting 23430 genes is conducted to identify the genes that confer resistance to metformin in prostate cancer cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE159467 | GEO | 2020/10/14

REPOSITORIES: GEO

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