Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ChIP-Seq of PRDM16 binding sites in E14 MGE

ABSTRACT: Identification of genome-wide PRDM16 binding sites in the medial ganglionic eminence of E14 mice

ORGANISM(S): Mus musculus

PROVIDER: GSE159729 | GEO | 2020/10/22

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

RNA-Seq of E14 MGE, Prdm16 WT vs cKO

Project description:This study aimed to understand the role of the transcriptional regulator Prdm16 in the development of cortical interneurons in the mouse. Prdm16 was knocked out in cells derived from the medial ganglionic eminence (MGE) by using an Nkx2.1-Cre driver line in combination with a line carrying floxed Prdm16 alleles and with a Cre-dependent tdTomato reporter line (Ai14). The sequencing data compares the gene expression profiles of dissected MGEs at embryonic day 14 (E14), a stage when cortical interneurons are being generated from MGE progenitors.

2020-10-22 | GSE159728 | GEO

Transcription profiling of rat ganglionic eminences and cerebral cortex at embryonic stages E12.5, E14 and E16

Project description:Gene expression profiling of the medial (MGE), lateral (LGE) and caudal (CGE) ganglionic eminence, and cerebral cortex (CTX) at various embryonic stages (E12.5, E14 and E16).

2008-04-19 | E-MEXP-570 | biostudies-arrayexpress

ChIP-Seq of PRDM16 binding sites in E14 MGE

Project description:ChIP-Seq of PRDM16 binding sites in E14 MGE

| PRJNA670345 | ENA

Multiomic sequencing of the MGE

Project description:Single-cell multiomic sequencing (RNA+ATAC in the same cells) of the E13.5 medial ganglionic eminence (MGE).

2021-09-22 | GSE165114 | GEO

Single-cell RNA-seq (Smart-seq2) of MGE of E13.5 mice

Project description:Single-cell RNA-seq of mitotically enriched cells in the medial ganglionic eminence (Dlx6 negative), as well as labeled cells using FlashTag technology.

2018-03-05 | GSE104157 | GEO

RNA-Seq of E14 MGE, Prdm16 WT vs cKO

Project description:RNA-Seq of E14 MGE, Prdm16 WT vs cKO

| PRJNA670344 | ENA

scRNA-seq of e14.5 MGE - WT vs. St18(-/-)

Project description:Medial ganglionic eminence was dissected from e14.5 mouse embryonic brain, dissociated and processed using 10X Genomics chemistry for single cell library creation. 2 experimental groups were analyzed: St18 null and wildtype littermate controls (2 biological replicates of each group)

2022-12-08 | GSE181349 | GEO

E14 MGE

Project description:E14 MGE

| PRJNA670339 | ENA

Bulk RNA-seq of the human fetal neocortex, lateral ganglionic eminence and medial ganglionic eminence at 7, 9, 11 and 20 post-conceptional weeks

Project description:Deep transcriptional profiling of the human neocortex, lateral ganglionic eminence (LGE) and medial ganglionic eminences (MGE), from 7 to 20 post-conceptional weeks (pcw), for de novo lincRNAs discovery and to establish a unique coding and non-coding gene signature for the three different regions.

2021-05-13 | E-MTAB-8893 | biostudies-arrayexpress

Expression data from purified medial ganglionic eminence (MGE) interneurons, 3 biological replicates

Project description:During development, newborn interneurons migrate throughout the embryonic brain. Here, we provide evidence that these interneurons act in a paracrine fashion to regulate developmental oligodendrocyte formation. Specifically, we show that medial ganglionic eminence (MGE) interneurons secrete factors that promote genesis of oligodendrocytes from glially-biased cortical precursors in culture. Moreover, when MGE interneurons are genetically ablated in vivo prior to their migration, this causes a deficit in cortical oligodendrogenesis. Modeling of the interneuron-precursor paracrine interaction using transcriptome data identifies the cytokine fractalkine as responsible for the pro-oligodendrocyte effect in culture. This paracrine interaction is important in vivo, since knockdown of the fractalkine receptor CX3CR1 in embryonic cortical precursors, or constitutive knockout of CX3CR1 causes decreased numbers of oligodendrocyte progenitor cells (OPCs) and oligodendrocytes in the postnatal cortex. Thus, in addition to their role in regulating neuronal excitability, interneurons act in a paracrine fashion to promote the developmental genesis of oligodendrocytes. We used microarrays to generate a list of expressed genes in purified medial ganglionic eminence (MGE) interneurons

2017-03-06 | GSE95696 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data