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TREM2 sustains macrophage-hepatocyte metabolic coordination in NAFLD and sepsis [Mouse_Kupffer_cell_small_RNA_seq]

ABSTRACT: The goals of this study are to assess the NAFLD-induced changes in expression of hepatic Kupffer cells (KCs) miRNAs, we conducted deep sequencing of small RNAs from KCs isolated from 8-week HFD-fed WT and Trem2-/- mice. Over 1000 miRNAs were identified in the hepatic macrophages. A set of miRNAs were upregulated in Trem2-/- versus WT hepatic macrophages, amongh which miR-106b was the most abundant miRNA in KCs.

ORGANISM(S): Mus musculus

PROVIDER: GSE160020 | GEO | 2021/02/17

REPOSITORIES: GEO

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TREM2 sustains macrophage-hepatocyte metabolic coordination in NAFLD and sepsis [Mouse_Kupffer_cell_RNA_seq]

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