MicroRNA-221/222 modulate intestinal T helper 17 cell response as a negative feedback rheostat downstream of IL-23

ABSTRACT: MicroRNA-221/222 receive activation signal from IL-23 and suppression signal from TGFb, and target Maf and IL-23R for degradation, therebt acting in an inflammatory arm of Th17 response, and works as a negative feedback rheostat to constrain otherwise feed-forward loop of inflammatory Th17 response in the gut.

ORGANISM(S): Mus musculus

PROVIDER: GSE160250 | GEO | 2021/03/03

REPOSITORIES: GEO