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Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE160272 | GEO | 2020/12/20

REPOSITORIES: GEO

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Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic.

Project description: Not available

| S-EPMC7732343 | biostudies-literature

Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic [RNA-Seq of whole olfactory mucosa]

Project description:Understanding how genes and experiences work in concert to generate phenotypic variability will provide a better understanding of individuality. Here, we considered this in the context of the main olfactory epithelium, a chemosensory structure with over a thousand distinct cell types, in mice. We identified a subpopulation of at least three types of olfactory sensory neurons, defined by receptor expression, whose abundances were sexually dimorphic. This subpopulation of olfactory sensory neurons was over-represented in sex-separated female mice and responded robustly to the male-specific semiochemicals 2-sec-butyl-4,5-dihydrothiazole and (methylthio)methanethiol. Sex-combined housing led to a robust attenuation of the female over-representation. Testing of Bax-/- mice revealed a Bax-dependence in generating the sexual dimorphism in sex-separated mice. Altogether, our results suggest a profound role of experience and activity in influencing homeostatic mechanisms to generate a robust sexually dimorphic phenotype in the main olfactory epithelium.

2020-12-20 | GSE160270 | GEO

Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic [pS6-IP-Seq of whole olfactory mucosa]

2020-12-20 | GSE160271 | GEO

Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic

Project description:Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic

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Mouse olfactory sensory neurons, main olfactory epithelium and main olfactory bulb

Project description:This SuperSeries is composed of the SubSeries listed below.

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Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic [RNA-Seq of whole olfactory mucosa]

Project description:Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic [RNA-Seq of whole olfactory mucosa]

| PRJNA672853 | ENA

Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic [pS6-IP-Seq of whole olfactory mucosa]

Project description:Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic [pS6-IP-Seq of whole olfactory mucosa]

| PRJNA672854 | ENA

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Project description:This SuperSeries is composed of the SubSeries listed below.

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Odorant Receptor Expression Frequency in Mature Olfactory Sensory Neurons Depends on Lhx2

Project description:This SuperSeries is composed of the SubSeries listed below.

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Sexually dimorphic gene expression emerges with embryonic genome activation and is dynamic throughout development

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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